Hurricane Betsy in September 1965 and Tropical Storm Frances in 1998 put the entire island under water. In 1956, Hurricane Flossy damaged the island. Grand Isle was hit by a 3.6-foot (1.1 m) storm surge on 22 August during the 1947 Atlantic hurricane season. A category 4 hurricane devastated Grand Isle on 29 September during the 1915 Atlantic hurricane season. In the 1909 Atlantic hurricane season the island was hit with a second 16-foot (5 m) storm surge. In the 1893 Atlantic hurricane season Grand Isle was devastated by a 16-foot (5 m) storm surge. In 1860, a 6-foot (2 m) storm surge and great winds resulted in the total devastation of the island. On average, the town and barrier island of Grand Isle has been affected by tropical storms or hurricanes every 2.68 years (since 1877), with direct hits on average every 7.88 years. Grand Isle has been repeatedly pummeled by hurricanes throughout its history. Direct access to Grand Isle's seat of parish government is 95 miles (153 km) away in suburban Jefferson Parish.

LA 1's automobile causeway at the west end of the island is the only land access to or from Grand Isle. Grand Isle's main street is the seaside start of Louisiana Highway 1 (LA 1), which stretches 436.2 miles (702.0 km) away to the northwest corner of the state, ending near Shreveport. The population was 1,005 as of the 2020 U.S census, down from 1,296 from the previous 2010 U.S census. The town of Grand Isle is statistically part of the New Orleans− Metairie− Kenner metropolitan statistical area, though it is not connected to New Orleans' continuous urbanized area. The island is at the mouth of Barataria Bay where it meets the gulf. state of Louisiana, located on a barrier island of the same name in the Gulf of Mexico.

Grand Isle is a town in Jefferson Parish in the U.S.

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